effects of vitex agnus castus on mice fetus development

vitex agnus castus (chasteberry) is a popular treatment for the management of female reproductive disorders including corpus luteum insufficiency, premenstrual syndrome (pms), menopausal symptoms, and insufficient milk production. according to developing situation of complementary medicine, and frequent use of this herb, it is important to examine its effects during pregnancy. in this research we studied its effects on mice development, and we focused on macroscopic parameters, such as crl (crown-rump length) and the weight of embryos, and diameter and the weight of placenta, and microscopic parameters such as the diameters of eye and lens of embryos. we found that vitex has special effects during different stages of mice development, for example it can improve the growth of embryos in 8 th and 9 th day of pregnancy (it causes significant increase in crl and weight of embryos). also, it may changes some microscopic parameters. these founding suggest that it should be used more cautiously during pregnancy.